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. 2017 Jun 10;79(6):988-991.
doi: 10.1292/jvms.17-0136. Epub 2017 Apr 21.

Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus

Junichi Namekawa  1 , Yoshiichi Takagi  1 , Kaoru Wakabayashi  1 , Yuki Nakamura  1 , Ayaka Watanabe  1 , Dai Nagakubo  1 , Mitsuyuki Shirai  1 , Fumitoshi Asai  1
Affiliations

Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus

Junichi Namekawa et al. J Vet Med Sci. .

Abstract

Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, and these epidemics appear to have emerged largely from changes in daily diet. In the present study, we compared effects of high-fat diet (HFD) and fructose-rich diet (FRD) in WBN/Kob-Leprfa (WBKDF) rats that spontaneously develop obesity, dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD and WBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF rats fed standard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD rats was significantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. The present study demonstrated that the 4-week feeding of HFD and FRD caused diet-induced obesity with a distinct phenotype in the glucose metabolism in WBKDF rats.

Keywords: WBN/Kob-Leprfa rat; diet-induced obesity; fructose-rich diet; high-fat diet; type 2 diabetes.

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Figures

Fig. 1.
Fig. 1.
Effects of the 4-week feeding of HFD and FRD on (A) the body weights (open circle, Wistar-STD; closed circle, WBKDF-STD; closed square, WBKDF-HFD; closed triangle, WBKDF-FRD), and (B) epididymal and (C) mesenteric fat weights in WBKDF rats. The fat weights were determined at 11 weeks of age. Data are expressed as mean ± SE (n=8). Different superscript letters (a, b, c) indicate significant differences between groups (P<0.05).
Fig. 2.
Fig. 2.
Effects of the 4-week feeding of HFD and FRD on plasma levels of (A) total cholesterol, (B) phospholipid and (C) triglyceride in WBKDF rats. Data are expressed as mean ± SE (n=8). Different superscript letters (a, b, c) indicate significant differences between groups (P<0.05).
Fig. 3.
Fig. 3.
Effects of the 4-week feeding of HFD and FRD on (A) plasma glucose concentrations and (B) plasma insulin concentrations in WBKDF rats (open circle, Wistar-STD; closed circle, WBKDF-STD; closed square, WBKDF-HFD; closed triangle, WBKDF-FRD). Data are expressed as mean ± SE (n=8). Different superscript letters (a, b, c) indicate significant differences between groups (P<0.05).
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References

    1. Akimoto T., Nakama K., Katsuta Y., Zhang X. J., Ohsuga M., Ishizaki M., Sawai N., Ozawa H.2008. Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr(fa)) rat. Biochem. Biophys. Res. Commun. 366: 556–562. doi: 10.1016/j.bbrc.2007.12.003 - DOI - PubMed
    1. Anderson P. J., Critchley J. A., Chan J. C., Cockram C. S., Lee Z. S., Thomas G. N., Tomlinson B.2001. Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality. Int. J. Obes. Relat. Metab. Disord. 25: 1782–1788. doi: 10.1038/sj.ijo.0801837 - DOI - PubMed
    1. Bandini L. G., Vu D., Must A., Cyr H., Goldberg A., Dietz W. H.1999. Comparison of high-calorie, low-nutrient-dense food consumption among obese and non-obese adolescents. Obes. Res. 7: 438–443. doi: 10.1002/j.1550-8528.1999.tb00431.x - DOI - PubMed
    1. Buettner R., Schölmerich J., Bollheimer L. C.2007. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15: 798–808. doi: 10.1038/oby.2007.608 - DOI - PubMed
    1. Catena C., Giacchetti G., Novello M., Colussi G., Cavarape A., Sechi L. A.2003. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am. J. Hypertens. 16: 973–978. doi: 10.1016/S0895-7061(03)01002-1 - DOI - PubMed