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Case Reports
. 2016 Oct-Dec;8(4):188-190.
doi: 10.4103/ijt.ijt_67_16.

Methotrexate in Alopecia Areata: A Report of Three Cases

Ana Batalla  1 , Ángeles Flórez  1 , Teresa Abalde  1 , Hugo Vázquez-Veiga  2
Affiliations
Case Reports

Methotrexate in Alopecia Areata: A Report of Three Cases

Ana Batalla et al. Int J Trichology. 2016 Oct-Dec.

Abstract

There are few studies about systemic treatment in severe cases of alopecia areata (AA), especially in the pediatric population. Although there is more experience with systemic corticosteroids, recent reports have suggested methotrexate (MTX) as an alternative treatment, with a relatively good outcome. We describe three cases of AA in children treated with MTX, two of them with successful results.

Keywords: Alopecia areata; methotrexate; treatment.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Case 1 – Progressive increase of hair density along methotrexate treatment: (a and c) 6 months after treatment; (b) 12 months after treatment; (d) 24 months after treatment
Figure 2
Figure 2
Case 2 – Successful hair regrowth in the eyebrows: (a) Previous to methotrexate; (b) 2 months after treatment; (c) 4 months after treatment
See this image and copyright information in PMC

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References

    1. Tosti A, Bellavista S, Iorizzo M. Alopecia areata: A long term follow-up study of 191 patients. J Am Acad Dermatol. 2006;55:438–41. - PubMed
    1. Royer M, Bodemer C, Vabres P, Pajot C, Barbarot S, Paul C, et al. Efficacy and tolerability of methotrexate in severe childhood alopecia areata. Br J Dermatol. 2011;165:407–10. - PubMed
    1. Hammerschmidt M, Mulinari Brenner F. Efficacy and safety of methotrexate in alopecia areata. An Bras Dermatol. 2014;89:729–34. - PMC - PubMed
    1. El-Zawahry BM, Bassiouny DA, Khella A, Zaki NS. Five-year experience in the treatment of alopecia areata with DPC. J Eur Acad Dermatol Venereol. 2010;24:264–9. - PubMed
    1. Friedland R, Tal R, Lapidoth M, Zvulunov A, Ben Amitai D. Pulse corticosteroid therapy for alopecia areata in children: A retrospective study. Dermatology. 2013;227:37–44. - PubMed

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