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Review
. 2017 Apr 12:12:2957-2978.
doi: 10.2147/IJN.S127683. eCollection 2017.

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Hossein Jahangirian  1 , Ensieh Ghasemian Lemraski  2 , Thomas J Webster  1 , Roshanak Rafiee-Moghaddam  3 , Yadollah Abdollahi  4
Affiliations
Review

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Hossein Jahangirian et al. Int J Nanomedicine. .

Abstract

This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine". Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

Keywords: cancer; drug delivery; green chemistry; nanoparticle.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
A schematic representation of some of the unique advantages of magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Abbreviation: BBB, blood–brain barrier.
Figure 2
Figure 2
Schematic illustration of the synthesis of soybean phospholipid-encapsulated MoS2. Abbreviations: MoS2, molybdenum disulfide; NIR, near infrared absorbing dyes.
Figure 3
Figure 3
Schematic image of different drug-delivering vehicles and releasing techniques between NCM and FA-CCM. Abbreviations: FA, folic acid; GSH, glutathione; PEG, poly(ethylene glycol); Cur, curmine; NCM, noncross-linked micelle; PDS, pyridyldisulfide; DTT, dithiothreitol.
Figure 4
Figure 4
A schematic illustration for the synthesis of hydrophilic CuInS2 QDs for in vitro bioimaging. Abbreviations: GSH, glutathione; QDs, quantum dots.
Figure 5
Figure 5
Schematic diagram for the synthesis of pullulan-stabilized AuNPs. Abbreviations: AuNPs, gold nanoparticles; EDC, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride.
Figure 6
Figure 6
Schematic image of the modification of SWCNTs with the antitumor drug DOX for targeting and accelerated destroying of breast cancer. Abbreviations: DOX, doxorubicin; FA, folic acid; PEG, poly(ethylene glycol); SWCNTs, single-walled carbon nanotubes; NIR, near-infrared.
Figure 7
Figure 7
One example of using CNTs as a multifunctional insulin carrier. Abbreviations: CNTs, carbon nanotubes; EDC, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NHS, N-hydroxysulfosuccinimide.
Figure 8
Figure 8
Schematic illustration of the preparing and in vitro osteogenic effect of PlGF-2-/BMP-2-loaded heparin–HTCC nanocomplexes. Abbreviations: BMP-2, bone morphogenic protein-2; PlGF, placental growth factor; GF, Dual-growth factor-loaded; HTCC, heparin–N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride.
Figure 9
Figure 9
Schematic image of transformable core–shell-based nanocarriers.
See this image and copyright information in PMC

References

    1. Ravichandran S. Green chemistry- a potential tool for chemical synthesis. Int J Chem Tech Res. 2010;2(4):2188–2191.
    1. White MA, Johnson JA, Koberstein JT, Turro NJ. Toward the syntheses of universal ligands for metal oxide surfaces: controlling surface functionality through click chemistry. J Am Chem Soc. 2006;128(35):11356–11357. - PubMed
    1. Arruebo M, Fernandez-Pacheco R, Ibarra MR, Santamaria J. Magnetic nanoparticles for drug delivery. Nano Today. 2007;2(3):22–32.
    1. Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem. 2004;14(21):61–75.
    1. Sun Z, Worden M, Thliveris JA, et al. Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA) Nanomedicine. 2016;12(7):1775–1784. - PubMed