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Case Reports
. 2017 Apr 14;3(3):228-229.
doi: 10.1016/j.jdcr.2017.02.019. eCollection 2017 May.

Novel use of apremilast for adjunctive treatment of recalcitrant pyoderma gangrenosum

Mary E Laird  1 , Lana X Tong  1 , Kristen I Lo Sicco  1 , Randie H Kim  1 , Shane A Meehan  1 , Andrew G Franks Jr  1
Affiliations
Case Reports

Novel use of apremilast for adjunctive treatment of recalcitrant pyoderma gangrenosum

Mary E Laird et al. JAAD Case Rep. .
No abstract available

Keywords: PG, pyoderma gangrenosum; TNF, tumor necrosis factor; apremilast; neutrophilic dermatoses; pyoderma gangrenosum.

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Figures

Fig 1
Fig 1
Pyoderma gangrenosum, clinical photographs. Back erosion at baseline (A) and after 5 months of apremilast (B). Thigh erosion at baseline (C) and after 5 months of apremilast (D).
See this image and copyright information in PMC

References

    1. Ahronowitz I., Harp J., Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol. 2012;13:191–211. - PubMed
    1. Wilson-Jones E., Winkelmann R.K. Superficial granulomatous pyoderma: a localized vegetative form of pyoderma gangrenosum. J Am Acad Dermatol. 1988;18:511–521. - PubMed
    1. Kim R.H., Lewin J., Hale C.S., Meehan S.A., Stein J., Ramachandran S. Vegetative pyoderma gangrenosum. Dermatol Online J. 2014;20 - PubMed
    1. Schett G., Sloan V.S., Stevens R.M., Schafer P. Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases. Ther Adv Musculoskelet Dis. 2010;2:271–278. - PMC - PubMed
    1. Marzano A.V., Fanoni D., Antiga E. Expression of cytokines, chemokines and other effector molecules in two prototypic autoinflammatory skin diseases, pyoderma gangrenosum and Sweet's syndrome. Clin Exp Immunol. 2014;178:48–56. - PMC - PubMed

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