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Review
. 2017 Oct;74(19):3439-3449.
doi: 10.1007/s00018-017-2530-0. Epub 2017 Apr 25.

Control of DNA integrity in skeletal muscle under physiological and pathological conditions

Yara Bou Saada  1 , Vlada Zakharova  1   2 , Boris Chernyak  2 , Carla Dib  1 , Gilles Carnac  3 , Svetlana Dokudovskaya  1 , Yegor S Vassetzky  4   5   6
Affiliations
Review

Control of DNA integrity in skeletal muscle under physiological and pathological conditions

Yara Bou Saada et al. Cell Mol Life Sci. 2017 Oct.

Abstract

Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.

Keywords: Aging; DNA damage; DNA repair; Oxidative stress.

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Fig. 1
Fig. 1
Physiological and pathological roles of ROS and DNA damage in muscle
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