Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep;178(6):852-870.
doi: 10.1111/bjh.14719. Epub 2017 Apr 25.

Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch  1   2   3   4 , Florence Nguyen-Khac  5 , Olivier A Bernard  1   2   3   4
Affiliations
Review

Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch et al. Br J Haematol. 2017 Sep.

Abstract

Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients' perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.

Keywords: chronic lymphocytic leukaemia; mutations; targeted therapy; tumour evolution.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources