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. 2017 Jun 12;23(33):7905-7909.
doi: 10.1002/chem.201701820. Epub 2017 May 15.

Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines

Marta Meazza  1 , Lars A Leth  1 , Jeremy D Erickson  1 , Karl Anker Jørgensen  1
Affiliations

Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines

Marta Meazza et al. Chemistry. .

Abstract

A new indium(III)-catalyzed reaction for the synthesis of a series of indolizine scaffolds has been developed. This methodology was highly efficient, allowing a low catalyst loading of 2 mol % (down to 0.5 mol %) and rendering the products in high yields through a 5-exo-dig aza-Conia-ene reaction. Furthermore, the possibility of incorporating an electrophile into the generated pyrrolidone ring in a one-pot synergistic fashion was demonstrated. Finally, based on experimental observations, a mechanism proposal was outlined.

Keywords: heterocycles; indium; indolizines; synergistic catalysis.

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