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Review
. 2017 Apr 26;15(5):126.
doi: 10.3390/md15050126.

A Review Study on Macrolides Isolated from Cyanobacteria

Mengchuan Wang  1 , Jinrong Zhang  2 , Shan He  3 , Xiaojun Yan  4
Affiliations
Review

A Review Study on Macrolides Isolated from Cyanobacteria

Mengchuan Wang et al. Mar Drugs. .

Abstract

Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of macrolides from cyanobacteria mainly manifest in the diversity of carbon skeletons, complexes of chlorinated thiazole-containing molecules and complex spatial configuration. In the present work, we systematically reviewed the structures and pharmacological activities of macrolides from cyanobacteria. Our data would help establish an effective support system for the discovery and development of cyanobacterium-derived macrolides.

Keywords: bioactivity; cyanobacteria; macrolides; secondary metabolites.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Anti-neoplastic profiling results for cyanobacterium-derived macrolides on different cell lines. Data are represented as IC50 [log(μM)].
Figure 2
Figure 2
Chemical structures of Compounds 1–11.
Figure 2
Figure 2
Chemical structures of Compounds 1–11.
Figure 3
Figure 3
Chemical structures of Compounds 12–16.
Figure 4
Figure 4
Chemical structures of Compounds 17–24.
Figure 5
Figure 5
Chemical structures of Compounds 25 and 26.
Figure 6
Figure 6
Chemical structures of Compounds 27–29.
Figure 7
Figure 7
Chemical structures of Compounds 30–38.
Figure 7
Figure 7
Chemical structures of Compounds 30–38.
Figure 8
Figure 8
Chemical structures of Compounds 39–46.
Figure 8
Figure 8
Chemical structures of Compounds 39–46.
Figure 9
Figure 9
Chemical structures of Compounds 47–51.
Figure 9
Figure 9
Chemical structures of Compounds 47–51.
Figure 10
Figure 10
Chemical structures of Compounds 52–54.
Figure 10
Figure 10
Chemical structures of Compounds 52–54.
Figure 11
Figure 11
Chemical structures of Compounds 55–57.
Figure 12
Figure 12
Chemical structures of Compounds 58–64.
See this image and copyright information in PMC

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