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. 2017 Apr 26;7(1):1204.
doi: 10.1038/s41598-017-01107-6.

Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness

P Guillaume Poliquin  1   2   3 , Mia Biondi  1 , Charlene Ranadheera  1   2 , Mable Hagan  1   2 , Alexander Bello  1 , Trina Racine  1   2 , Mark Allan  1 , Duane Funk  4 , Gregory Hansen  5 , B J Hancock  2 , Murray Kesselman  2 , Todd Mortimer  6 , Anand Kumar  2   7 , Shane Jones  1 , Anders Leung  1 , Allen Grolla  1 , Kaylie N Tran  1 , Kevin Tierney  1 , Xiangguo Qiu  1   2 , Darwyn Kobasa  1   2 , James E Strong  8   9   10
Affiliations

Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness

P Guillaume Poliquin et al. Sci Rep. .

Abstract

Critical care needs have been rising in recent decades as populations age and comorbidities increase. Sepsis-related admissions to critical care contribute up to 50% of volume and septic shock carries a 35-54% fatality rate. Improvements in sepsis-related care and mortality would have a significant impact of a resource-intensive area of health care delivery. Unfortunately, research has been hampered by the lack of an animal model that replicates the complex care provided to humans in an intensive care unit (ICU). We developed a protocol to provide full ICU type supportive care to Rhesus macaques. This included mechanical ventilation, continuous sedation, fluid and electrolyte management and vasopressor support in response to Ebolavirus-induced septic shock. The animals accurately recapitulated human responses to a full range of ICU interventions (e.g. fluid resuscitation). This model can overcome current animal model limitations by accurately emulating the complexity of ICU care and thereby provide a platform for testing new interventions in critical care and sepsis without placing patients at risk.

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Conflict of interest statement

The authors declare that they have no competing interests.

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