Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Apr 7:4:25.
doi: 10.21037/sci.2017.03.06. eCollection 2017.

Fetal hematopoietic stem cells are making waves

Bridget Waas  1   2 , Ivan Maillard  1   2   3
Affiliations
Editorial

Fetal hematopoietic stem cells are making waves

Bridget Waas et al. Stem Cell Investig. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Successive waves of hematopoiesis during development in mice. The first wave (in purple) originates primarily in the yolk sac (Y.S.) to produce primitive red blood cells and macrophages. A second wave (in blue) consists of erythroid and myeloid progenitors (EMP). The black curve refers to hematopoiesis driven by developmentally restricted hematopoietic stem cells (drHSC), as recently described by Beaudin et al. These lymphoid-biased HSCs can reconstitute lethally irradiated recipients after experimental transplantation, but spontaneously disappear before adulthood in their native environment. In parallel, conventional fetal HSCs (fHSC) give rise to the quiescent adult HSCs that sustain post-natal hematopoiesis.
See this image and copyright information in PMC

Comment on

References

    1. Lorenz E, Uphoff D, Reid TR, et al. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 1951;12:197-201. - PubMed
    1. Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988;241:58-62. 10.1126/science.2898810 - DOI - PubMed
    1. Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963;197:452-4. 10.1038/197452a0 - DOI - PubMed
    1. Eaves CJ. Hematopoietic stem cells: concepts, definitions, and the new reality. Blood 2015;125:2605-13. 10.1182/blood-2014-12-570200 - DOI - PMC - PubMed
    1. Bowie MB, Kent DG, Dykstra B, et al. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A 2007;104:5878-82. 10.1073/pnas.0700460104 - DOI - PMC - PubMed

LinkOut - more resources