The evolving landscape of treatment for advanced gastric cancer and the role of anti-angiogenic therapy: implications from results of the INTEGRATE study
- PMID: 28447064
- PMCID: PMC5388629
- DOI: 10.21037/tgh.2017.02.02
The evolving landscape of treatment for advanced gastric cancer and the role of anti-angiogenic therapy: implications from results of the INTEGRATE study
Conflict of interest statement
Conflicts of Interest: Nick Pavlakis is a consultant and has received honoraria from Roche, Eli Lily, Bayer; and has received grant funding from Bayer. Malinda Itchins has received honorarium from Pfizer, and has received travel support from Sanofi, Novartis, Amgen, BMS.
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Comment on
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Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.J Clin Oncol. 2016 Aug 10;34(23):2728-35. doi: 10.1200/JCO.2015.65.1901. Epub 2016 Jun 20. J Clin Oncol. 2016. PMID: 27325864 Free PMC article. Clinical Trial.
References
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- Hironaka S, Ueda S, Yasui H, et al. Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial. J Clin Oncol 2013;31:4438-44. 10.1200/JCO.2012.48.5805 - DOI - PubMed
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- Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-97. 10.1016/S0140-6736(10)61121-X - DOI - PubMed
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