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Case Reports
. 2017 May 31;15(2):190-193.
doi: 10.9758/cpn.2017.15.2.190.

Low-dose Clozapine-induced Seizure: A Case Report

Abdullah Bolu  1 , Süleyman Akarsu  2 , Erdal Pan  1 , Emre Aydemir  3 , Taner Oznur  4
Affiliations
Case Reports

Low-dose Clozapine-induced Seizure: A Case Report

Abdullah Bolu et al. Clin Psychopharmacol Neurosci. .

Abstract

Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.

Keywords: Adverse effects; Clozapine; Safety; Seizures.

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Figures

Fig. 1
Fig. 1
Bilateral diffuse epileptic activity with 200 mg/day clozapine use.
Fig. 2
Fig. 2
No abnormality at the electroencephalography performed at 4 months after the seizures with 100 mg/day clozapine and 1,000 mg/day valproic acid use.
See this image and copyright information in PMC

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