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Clinical Trial
. 2017 Jun;38(6):1151-1155.
doi: 10.3174/ajnr.A5178. Epub 2017 Apr 27.

Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study

L Pierot  1 , I Gubucz  2 , J H Buhk  3 , M Holtmannspötter  4 , D Herbreteau  5 , L Stockx  6 , L Spelle  7 , J Berkefeld  8 , A-C Januel  9 , A Molyneux  10 , J V Byrne  10 , J Fiehler  3 , I Szikora  2 , X Barreau  11
Affiliations
Clinical Trial

Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study

L Pierot et al. AJNR Am J Neuroradiol. 2017 Jun.

Abstract

Background and purpose: Flow disruption with the Woven EndoBridge (WEB) device is an innovative technique for the endovascular treatment of wide-neck bifurcation aneurysms. The initial version of the device (WEB Double-Layer) was evaluated in the WEB Clinical Assessment of IntraSaccular Aneurysm Therapy (WEBCAST) study, whereas the French Observatory study evaluated both WEB Double-Layer and Single-Layer versions of the device. WEBCAST 2 was designed to evaluate the WEB Single-Layer with Enhanced Visualization.

Materials and methods: Patients with wide-neck bifurcation aneurysms for which WEB treatment was possible were included. Clinical data including adverse events and clinical status at 1 month and 1 year were collected and analyzed. A core laboratory evaluated anatomic results at 1 year following the procedure.

Results: Ten European neurointerventional centers included 55 patients (38 women; 27-77 years of age; mean, 54.4 ± 10.0 years) with 55 aneurysms. Aneurysm locations were the middle cerebral artery in 25 aneurysms (45.5%), the anterior communicating artery in 16 (29.1%), the basilar artery in 9 (16.4%), and the internal carotid artery terminus in 5 (9.1%). Procedural morbidity and mortality at 1 month were, respectively, 1.8% (1/55 patients) and 0.0% (0/55 patients). Morbidity and mortality at 1 year were, respectively, 3.9% (2/51 patients) and 2.0% (1/51 patients). At 1 year, complete occlusion was observed in 27/50 aneurysms (54.0%); neck remnant, in 13/50 (26.0%); and aneurysm remnant, in 10/50 (20.0%) (adequate occlusion in 40/50, 80.0%).

Conclusions: WEBCAST 2 confirms the high safety and efficacy of WEB aneurysm treatment demonstrated in the WEBCAST and French Observatory studies.

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Comment in

  • Safety and Efficacy of Aneurysm Treatment with the WEB.
    Pelz DM, Lownie SP. Pelz DM, et al. AJNR Am J Neuroradiol. 2017 Dec;38(12):E109. doi: 10.3174/ajnr.A5387. Epub 2017 Sep 21. AJNR Am J Neuroradiol. 2017. PMID: 28935623 Free PMC article. No abstract available.
  • Reply.
    Pierot L. Pierot L. AJNR Am J Neuroradiol. 2017 Dec;38(12):E110. doi: 10.3174/ajnr.A5416. Epub 2017 Sep 21. AJNR Am J Neuroradiol. 2017. PMID: 28935627 Free PMC article. No abstract available.

References

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