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. 2016;41(4):386-391.
doi: 10.5114/ceji.2016.65138. Epub 2017 Jan 24.

Neutrophil to lymphocyte ratio is associated with proximal/middle segment of the LAD lesions in patients with ST segment elevation infarction

Ozlem Arican Ozluk  1 , Mustafa Yılmaz  1 , Dursun Topal  2 , Erhan Tenekecioglu  1 , Tezcan Peker  1 , Selcuk Kanat  1 , Kemal Karaagac  1 , Fahriye Vatansever  1 , Utku Parlak  1
Affiliations

Neutrophil to lymphocyte ratio is associated with proximal/middle segment of the LAD lesions in patients with ST segment elevation infarction

Ozlem Arican Ozluk et al. Cent Eur J Immunol. 2016.

Abstract

Introduction: Neutrophil to lymphocyte ratio (NLR) was revaled to have a close relation with atherosclerotic cardiovascular disease. The relationship between NLR and culprit plaque localization has never been studied.

Aim of the study: To evaluate the association between NLR and unstable plaque localization of left anterior descending artery (LAD) in anterior miyocardial infarction patients.

Material and methods: Patients admitted to our hospital with acute anterior STEMI were included. Fifhy-eight patients who have single-vessel disease at LAD and their hematological parameters were analyzed retrospectively. Proximal segment of LAD lesions were groupped as Group I and mid segment of the LAD lesion groupped as Group II. The groups were compared according to their NLR and other parameters.

Results: Between group I (n = 41, mean age 52.5 ±12.7) and group II (n = 17, mean ages 52.0 ±10.8); NLR, were significantly higher in group I compared to the group II (6.9 ±5.6 vs. 3.3 ±2.0, p = 0.01). In group I, left ventricular ejection fraction (LVEF) was significantly lower (p = 0.02). In correlation analyzes, NLR was positively correlated with CK MB (r = 0.32, p = 0.01) and negatively correlated with LVEF (r = -0.28, p = 0.03).

Conclusions: The present study demonstrated that anterior myocardial infarction patients with high NLR had a greater possibility having proximal culprit lesion on the LAD. Therefore NLR can be used as a useful tool to culprit plaque localization in patients with acute miyocardial infarction patients.

Keywords: acute coronary syndrome; coronary artery disease; neutrophil to lymphocyte ratio.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Receiver operating characteristic (ROC) curve analysis for prediction of the level of culprit lesion by (NLR). The area under the curve AUC) is 0.712 (95% CI: 0.581-0.843; p = 0.012) for NLR
See this image and copyright information in PMC

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