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. 1988 Nov;62(11):4398-402.
doi: 10.1128/JVI.62.11.4398-4402.1988.

DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation

C E Ibanez  1 , A Garcia, U Stober-Grässer, J S Lipsick
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DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation

C E Ibanez et al. J Virol. 1988 Nov.

Abstract

The product of the v-myb oncogene of avian myeloblastosis virus is a nuclear protein with an associated DNA-binding activity. We demonstrated that the highly conserved amino-terminal domain of p48v-myb is required for its associated DNA-binding activity. This activity is not required for the nuclear localization of p48v-myb. Furthermore, the associated DNA-binding activity and nuclear localization of p48v-myb together are not sufficient for transformation.

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