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. 1988 Oct;85(19):7159-63.
doi: 10.1073/pnas.85.19.7159.

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor

S Cotecchia  1 , D A Schwinn, R R Randall, R J Lefkowitz, M G Caron, B K Kobilka
Affiliations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor

S Cotecchia et al. Proc Natl Acad Sci U S A. 1988 Oct.

Abstract

The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism.

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References

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