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Meta-Analysis
. 2017 Jun 6;8(23):37367-37376.
doi: 10.18632/oncotarget.16959.

An inverse association between tea consumption and colorectal cancer risk

Yuetong Chen  1   2 , Yuan Wu  3 , Mulong Du  2   4   5 , Haiyan Chu  2 , Lingjun Zhu  6 , Na Tong  2 , Zhengdong Zhang  2   4 , Meilin Wang  2   4 , Dongying Gu  1 , Jinfei Chen  1   2
Affiliations
Meta-Analysis

An inverse association between tea consumption and colorectal cancer risk

Yuetong Chen et al. Oncotarget. .

Abstract

It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87-1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0.001, I2 = 43.4%). Stratified analysis revealed that tea, especially green tea, had a protective effect among female and rectal cancer patients. Particularly, the dose-response analysis showed that there was a significant inverse association between an increment of 1 cup/day of tea consumption and colorectal cancer risk in the subgroup of the green tea drinking (OR = 0.98, 95% CI = 0.96-1.01, Pnonlinear = 0.003) and female (OR = 0.68, 95% CI = 0.56-0.81, Pnonlinear < 0.001). Our findings indicate that tea consumption has an inverse impact on colorectal cancer risk, which may have significant public health implications in the prevention of colorectal cancer and further similar researches.

Keywords: colorectal cancer; inverse association; tea consumption.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have declared that no competing financial interest exists.

Figures

Figure 1
Figure 1. Flowchart of study selection
Figure 2
Figure 2. Forest plot of tea consumption and colorectal cancer risk
HCC, hospital-based case-control study; PCC, population-based case-control study; CRC, colorectal cancer; CC, colon cancer; RC, rectal cancer; M, male; F, female.
Figure 3
Figure 3. Dose-response association between tea consumption and colorectal cancer risk
See this image and copyright information in PMC

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