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Comment
. 2017 Apr 28;18(1):79.
doi: 10.1186/s13059-017-1219-x.

Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance

Affiliations
Comment

Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance

Elizabeth A Winzeler. Genome Biol. .

Abstract

A longitudinal analysis of malaria parasite genomes has revealed new markers that can be used in public health efforts to limit the spread of multidrug-resistant malaria.

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Figures

Fig. 1
Fig. 1
Homology model of the Kelch13 protein showing the positions of mutations detected in the study in a side view (left) and frontal view (right). Mutations are located in the Kelch domain, in some cases near the central cavity (C580Y and A675Y) that is involved in protein binding. The model was constructed using SwissModel and pdb template 4yy8.1.A

Comment on

References

    1. Cerqueira GC, Cheeseman IH, Schaffner SF, Nair S, McDew-White M, Phyo AP, et al. Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance in western Thailand. Genome Biol. 2017;18. doi:10.1186/s13059-017-1204-4. - PMC - PubMed
    1. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014;505:50–5. doi: 10.1038/nature12876. - DOI - PMC - PubMed
    1. Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014;371:411–23. doi: 10.1056/NEJMoa1314981. - DOI - PMC - PubMed
    1. Cheeseman IH, Miller BA, Nair S, Nkhoma S, Tan A, Tan JC, et al. A major genome region underlying artemisinin resistance in malaria. Science. 2012;336:79–82. doi: 10.1126/science.1215966. - DOI - PMC - PubMed
    1. Straimer J, Gnadig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, et al. Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science. 2015;347:428–31. doi: 10.1126/science.1260867. - DOI - PMC - PubMed