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Review
. 2017 Jun;105(6):711-719.
doi: 10.1007/s12185-017-2243-z. Epub 2017 Apr 28.

CMML: Clinical and molecular aspects

Raphael Itzykson  1   2 , Matthieu Duchmann  3 , Nolwenn Lucas  3 , Eric Solary  3   4
Affiliations
Review

CMML: Clinical and molecular aspects

Raphael Itzykson et al. Int J Hematol. 2017 Jun.

Abstract

Chronic Myelomonocytic Leukemia is a chronic myeloid neoplasm occurring mostly in the elderly with overlapping features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) characterized by chronic monocytosis. Recent progresses in the molecular and cellular pathogenesis of CMML have stirred a renewed interest in this clinically heterogeneous disorder. Here, we review the recent progresses in the biology of CMML and how it affects its current and future clinical management.

Keywords: Chronic myelomonocytic leukemia; Myelodysplastic; Myeloproliferative.

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