Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase
- PMID: 28455710
- DOI: 10.1007/978-3-319-54090-0_8
Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase
Abstract
Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.
Similar articles
-
Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis.Nitric Oxide. 2006 Nov;15(3):177-86. doi: 10.1016/j.niox.2006.03.009. Epub 2006 May 2. Nitric Oxide. 2006. PMID: 16647869 Review.
-
CpG oligodeoxynucleotide and double-stranded RNA synergize to enhance nitric oxide production and mRNA expression of inducible nitric oxide synthase, pro-inflammatory cytokines and chemokines in chicken monocytes.Innate Immun. 2011 Apr;17(2):137-44. doi: 10.1177/1753425909356937. Epub 2010 Jan 18. Innate Immun. 2011. PMID: 20083501
-
Nitric oxide synthase in innate and adaptive immunity: an update.Trends Immunol. 2015 Mar;36(3):161-78. doi: 10.1016/j.it.2015.01.003. Epub 2015 Feb 13. Trends Immunol. 2015. PMID: 25687683 Review.
-
Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example.Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):37-43. doi: 10.1111/bcpt.12139. Epub 2013 Oct 21. Basic Clin Pharmacol Toxicol. 2014. PMID: 24107256 Review.
-
Inducible nitric oxide synthase (iNOS): role in asthma pathogenesis.Indian J Biochem Biophys. 2007 Oct;44(5):303-9. Indian J Biochem Biophys. 2007. PMID: 18341205 Review.
Cited by
-
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.Int J Nanomedicine. 2020 Sep 7;15:6579-6592. doi: 10.2147/IJN.S261041. eCollection 2020. Int J Nanomedicine. 2020. PMID: 32982219 Free PMC article.
-
Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol.Medicina (Kaunas). 2019 Nov 18;55(11):747. doi: 10.3390/medicina55110747. Medicina (Kaunas). 2019. PMID: 31752240 Free PMC article.
-
Multifaceted role of nitric oxide in vascular dementia.Med Gas Res. 2025 Dec 1;15(4):496-506. doi: 10.4103/mgr.MEDGASRES-D-24-00158. Epub 2025 Apr 29. Med Gas Res. 2025. PMID: 40300885 Free PMC article. Review.
-
The protective role of localized nitric oxide production during inflammation may be mediated by the heme oxygenase-1/carbon monoxide pathway.Biochem Biophys Rep. 2020 Jul 24;23:100790. doi: 10.1016/j.bbrep.2020.100790. eCollection 2020 Sep. Biochem Biophys Rep. 2020. PMID: 32760814 Free PMC article.
-
Novel Therapeutics for Diabetic Retinopathy and Diabetic Macular Edema: A Pathophysiologic Perspective.Front Physiol. 2022 Feb 18;13:831616. doi: 10.3389/fphys.2022.831616. eCollection 2022. Front Physiol. 2022. PMID: 35250632 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources