Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul 26;398(8):857-870.
doi: 10.1515/hsz-2017-0111.

Rhadinoviral interferon regulatory factor homologues

Sandra Koch  1 , Thomas F Schulz  1
Affiliations
Review

Rhadinoviral interferon regulatory factor homologues

Sandra Koch et al. Biol Chem. .

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.

Keywords: KSHV; antiviral mechanisms; cellular homologues; rhadinovirus; viral interferon regulatory factor.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources