Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Jul:186:196-199.
doi: 10.1016/j.jpeds.2017.03.053. Epub 2017 Apr 26.

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B Mulkey  1 , Raghu H Ramakrishnaiah  2 , Robert C McKinstry  3 , Taeun Chang  4 , Amit M Mathur  3 , Dennis E Mayock  5 , Krisa P Van Meurs  6 , G Bradley Schaefer  2 , Chunqiao Luo  2 , Shasha Bai  2 , Sandra E Juul  5 , Yvonne W Wu  7
Affiliations
Randomized Controlled Trial

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B Mulkey et al. J Pediatr. 2017 Jul.

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores.

Trial registration: ClinicalTrials.gov: NCT01913340.

Keywords: brain volumetrics; diffusion weighted imaging; neuroprotection; newborn.

PubMed Disclaimer

Publication types

Associated data