Preliminary investigation of preoperative pregabalin and total intravenous anesthesia doses: a randomized controlled trial

Abstract

Study objective: To determine the efficacy of 2 different doses (150-300mg) of preoperative pregabalin on propofol and remifentanil doses for total intravenous anesthesia in laparoscopic cholecystectomy.

Design: Prospective, randomized, placebo-controlled, double-blinded study.

Setting: Training and research hospital.

Patients: Forty-eight adult, American Society of Anesthesiologists physical status 1 and 2 patients.

Interventions: Patients were randomly assigned to 3 groups to receive orally 1hour before surgery, a placebo group (group 1), pregabalin 150mg (group 2), or pregabalin 300mg (group 3).

Measurements: In the operating room, heart rate, systolic and diastolic blood pressures, SpO₂, bispectral index, and body temperature were recorded just before anesthesia induction; 1 and 5minutes after induction; and at minutes 10, 15, 20, 25, 30, 35, and 40 of the surgery. Required propofol and remifentanil doses to obtain bispectral index value less than 60 were also recorded.

Main results: The remifentanil doses used in the pregabalin groups at minutes 10, 15, 20, 25, and 30 and propofol doses at minutes 15, 20, 25, and 30 were statistically significantly lower in comparison to the placebo group.

Conclusion: The observations provide preliminary evidence that preoperative pregabalin may decrease anesthetic agent requirement in total intravenous anesthesia patients.

Keywords: Anesthesia; BIS; Pregabalin; TIVA.