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Review
. 2017 Oct;23(19-20):1152-1159.
doi: 10.1089/ten.TEA.2016.0538. Epub 2017 May 19.

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials<sup/>

Jenna L Dziki  1   2 , Luai Huleihel  1 , Michelle E Scarritt  1   3 , Stephen F Badylak  1   2   3
Affiliations
Review

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials<sup/>

Jenna L Dziki et al. Tissue Eng Part A. 2017 Oct.

Abstract

Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

Keywords: ECM bioscaffolds; host response; macrophage.

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Conflict of interest statement

No competing financial interests exist.

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