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Comparative Study
. 1988 Jan-Mar;2(1):15-8.

Interferon gamma does not induce antiviral resistance in T lymphocytes

M Zucca  1 , G Gribaudo, B Ferrara, G Cavallo, S Landolfo
Affiliations
  • PMID: 2845724
Comparative Study

Interferon gamma does not induce antiviral resistance in T lymphocytes

M Zucca et al. J Biol Regul Homeost Agents. 1988 Jan-Mar.

Abstract

We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses.

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