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Review
. 2017 Jun;37(2):303-315.
doi: 10.1016/j.cll.2017.01.005. Epub 2017 Mar 11.

Carbapenem-Resistant Enterobacteriaceae

Alina Iovleva  1 , Yohei Doi  2
Affiliations
Review

Carbapenem-Resistant Enterobacteriaceae

Alina Iovleva et al. Clin Lab Med. 2017 Jun.

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae) are particularly of concern because they tend to spread, and treatment is difficult. The carbapenemase groups most commonly encountered include KPC, NDM, and OXA-48. Treatment options are limited and include combinations of polymyxins, tigecycline, aminoglycosides, or carbapenems; newer agents with activity against CRE and better safety profiles are becoming available and will likely emerge as the preferred therapy.

Keywords: Carbapenemase; KPC; Rapid diagnosis.

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Conflict of interest statement

Transparency declarations

Y.D. has served on advisory boards for Meiji, Achaogen, Allergan, Curetis, and has received research funding from The Medicines Company for a study unrelated to this work. A.I declares no conflicts of interest.

Figures

Figure 1
Figure 1
Example of Carba NP test. Wells 1–7 are carbapenemase-producing strains, wells 8 and 9 are non-carbapanemase-producing strains. Photographed after 1 hour of reaction.
See this image and copyright information in PMC

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MeSH terms