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Case Reports
. 2017;56(9):1053-1055.
doi: 10.2169/internalmedicine.56.7405. Epub 2017 May 1.

Thrombosis in an Internal Jugular Vein and an Upper Limb Deep Vein Treated with Edoxaban

Mizuho Toratani  1 , Akiko Hayashi  1 , Naoki Nishiyama  1 , Hidehiko Nakamura  1 , Ryuji Chida  1 , Takaaki Komatsu  1 , Shiro Nakahara  1 , Sayuki Kobayashi  1 , Isao Taguchi  1
Affiliations
Case Reports

Thrombosis in an Internal Jugular Vein and an Upper Limb Deep Vein Treated with Edoxaban

Mizuho Toratani et al. Intern Med. 2017.

Abstract

A 45-year-old man complained of swelling of the left side of his neck and left upper limb. Ultrasonography and enhanced computed tomography (CT) revealed thrombosis of the left internal jugular, subclavian, and brachiocephalic vein. Based on various examinations, the patient was diagnosed with idiopathic venous thrombosis early in his clinical course. There were no findings to suggest malignancy or abnormal coagulability. However, two months after the start of treatment, the patient was diagnosed with gastric cancer. Despite the presence of Trousseau syndrome, treatment with edoxaban (an oral anticoagulant), reduced the swelling dramatically without any bleeding complications.

Keywords: Trousseau syndrome; oral anticoagulant; upper-extremity deep vein thrombosis.

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Figures

Figure 1.
Figure 1.
Ultrasonography images (color flow Doppler imaging). A: A short-axis view of the left side of the neck. On the first ultrasound examination, a hyperechoic region of the thrombus in the left jugular vein thrombus coexisted with a hypoechoic region, which occluded the left jugular vein (arrow). B: The left subclavian approach. On the first ultrasound, a thrombus was present in the left subclavian vein (triangle) and another thrombus was present in the left brachiocephalic vein (arrow). C: The left subclavian approach. After 1 month of edoxaban treatment, the thrombi in the left subclavian vein (triangle) and left brachiocephalic vein (arrow) were smaller, and blood flow through these veins was increased.
Figure 2.
Figure 2.
Contrast-enhanced computed tomography showing thrombi in the left internal jugular vein, left subclavian vein, and left brachiocephalic vein (arrows).
See this image and copyright information in PMC

References

    1. Sajid MS, Ahmed N, Desai M, Baker D, Hamilton G. Upper limb deep vein thrombosis: a literature review to streamline the protocol for management. Acta Haematol 118: 10-18, 2007. - PubMed
    1. Varki A. Trousseau's syndrome: multiple definitions and multiple mechanisms. Blood 110: 1723-1727, 2007. - PMC - PubMed
    1. Verso M, Agnelli G. Venous thromboembolism associated with long term use of central venous catheters in cancer patients. J Clin Oncol 19: 3665-3675, 2003. - PubMed
    1. Lindbland B, Tengborn L, Bergqvist D. Deep vein thrombosis of the axillary and subclavian veins: epidemiological data, effects of different types of treatment and late sequelae. Eur J Vasc Surg 2: 161-165, 1988. - PubMed
    1. Shameem M, Akhtar J, Bhargava R, Ahmed Z, Baneen U, Khan NA. Internal jugular vein thrombosis: a rare presentation of mediastinal lymphoma. Respir Med CME 3: 273-275, 2010.

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