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Comparative Study
. 1988 Sep 1;254(2):613-5.
doi: 10.1042/bj2540613.

Receptor binding of guinea pig and pig vasoactive intestinal peptides by rat lung

S Paul  1 , D J Volle, J Currie
Affiliations
Comparative Study

Receptor binding of guinea pig and pig vasoactive intestinal peptides by rat lung

S Paul et al. Biochem J. .

Abstract

Guinea pig vasoactive intestinal peptide (gpVIP) differs from other mammalian VIPs in four of its 28 amino acid residues. In the present study, the gpVIP displaced 125I-labelled pig VIP (pVIP) binding by rat lung membranes with 7.7-fold lower potency than pVIP. Degradation of gpVIP by rat lung membranes, assessed by radioimmunoassay and h.p.l.c., was 1.9-fold greater than that of pVIP. This difference in degradation of the two peptides was not large enough to account for the lower receptor-binding potency of gpVIP. The amino acid residues that distinguish pVIP from gpVIP are likely to contribute to the interaction of VIP with receptors and peptide hydrolases in lung membranes.

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