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. 1988 Sep 30;155(3):1459-63.
doi: 10.1016/s0006-291x(88)81305-6.

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats

Y Naitoh  1 , J Fukata, T Tominaga, Y Nakai, S Tamai, K Mori, H Imura
Affiliations

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats

Y Naitoh et al. Biochem Biophys Res Commun. .

Abstract

In order to assess the effect of interleukin-6 on the hypothalamo-pituitary-adrenal axis, we administered recombinant human interleukin-6 to conscious, freely-moving rats. The intravenous injection of interleukin-6 significantly increased the plasma level of adrenocorticotropic hormone 30 min after the injection in a dose-related manner. Immunoneutralization of corticotropin-releasing hormone blocked the stimulatory effects of interleukin-6 on adrenocorticotropic hormone secretion. These observations suggest that interleukin-6 stimulates the secretion of adrenocorticotropic hormone through the corticotropin-releasing hormone and is possibly involved in the interaction between the neuroendocrine and immune system.

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