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Review
. 2017 Sep;17(9):e280-e292.
doi: 10.1016/S1473-3099(17)30234-7. Epub 2017 Apr 28.

Insights from clinical research completed during the west Africa Ebola virus disease epidemic

Amanda Rojek  1 , Peter Horby  1 , Jake Dunning  2
Affiliations
Review

Insights from clinical research completed during the west Africa Ebola virus disease epidemic

Amanda Rojek et al. Lancet Infect Dis. 2017 Sep.

Abstract

The west Africa Ebola virus disease (EVD) epidemic was extraordinary in scale. Now that the epidemic has ended, it is a relevant time to examine published studies with direct relevance to clinical care and, more broadly, to examine the implications of the clinical research response mounted. Clinically relevant research includes literature detailing risk factors for and clinical manifestations of EVD, laboratory and other investigation findings in patients, experimental vaccine and therapeutic clinical trials, and analyses of survivor syndrome. In this Review, we discuss new insights from patient-oriented research completed during the west Africa epidemic, identify ongoing knowledge gaps, and suggest priorities for future research.

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Conflict of interest statement

Declaration of interests

We declare no competing interests. The authors were investigators for two clinical trials described in this Review (TKM-130803 and brincidofovir trials).

Figures

Figure
Figure. Significant research advances during west Africa Ebola virus disease epidemic
Adapted from Bausch and Rojek (2016). (A) WHO holds consultation on potential Ebola therapeutics and vaccines. (B) WHO Response Team publishes first large observational patient data set. (C) Interim results of VSV-ZEBOV vaccine trial published. (D) Molecular evidence for sexual transmission published. (E) First clinical trial of experimental treatment (convalescent plasma) published.
See this image and copyright information in PMC

Comment in

References

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