Causal variants in autoimmune disease: a commentary on a recent published fine-mapping algorithm analysis in genome-wide association studies study

Jiunn-Diann Lin^{1

2

3}, Chao-Wen Cheng¹

Affiliations

¹ Graduate Institute of Clinical Medicine, Department of Internal Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Division of Endocrinology, Department of Internal Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Editorial

Jiunn-Diann Lin et al. Ann Transl Med. 2017 Mar.

. 2017 Mar;5(6):151.

doi: 10.21037/atm.2017.02.26.

Jiunn-Diann Lin^{1

2

3}, Chao-Wen Cheng¹

¹ Graduate Institute of Clinical Medicine, Department of Internal Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Division of Endocrinology, Department of Internal Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Farh KK, et al. Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29. Nature. 2015. PMID: 25363779 Free PMC article.

1. Farh KK, Marson A, Zhu J, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2015;518:337-43. 10.1038/nature13835 - DOI - PMC - PubMed
1. Tomer Y, Huber A. The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun 2009;32:231-9. 10.1016/j.jaut.2009.02.007 - DOI - PMC - PubMed
1. Tomer Y, Davies TF. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 2003;24:694-717. 10.1210/er.2002-0030 - DOI - PubMed
1. Lu R. Interferon regulatory factor 4 and 8 in B-cell development. Trends Immunol 2008;29:487-92. 10.1016/j.it.2008.07.006 - DOI - PMC - PubMed
1. Chrabot BS, Kariuki SN, Zervou MI, et al. Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis. Genes Immun 2013;14:471-8. 10.1038/gene.2013.42 - DOI - PMC - PubMed