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. 1988 Sep;7(9):2795-9.
doi: 10.1002/j.1460-2075.1988.tb03134.x.

Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients

D S Anson  1 , D J Blake, P R Winship, D Birnbaum, G G Brownlee
Affiliations

Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients

D S Anson et al. EMBO J. 1988 Sep.

Abstract

The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3' of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.

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References

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