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. 1988 Sep 1;154(1):85-7.
doi: 10.1016/0014-2999(88)90367-6.

Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

P J Birch  1 , C J Grossman, A G Hayes
Affiliations

Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

P J Birch et al. Eur J Pharmacol. .

Abstract

Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate acts as a weak competitive antagonist. The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.

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