Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;82(5):1798-802.
doi: 10.1172/JCI113794.

Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors

S C Kukreja  1 , D H Shevrin, S A Wimbiscus, P R Ebeling, J A Danks, C P Rodda, W I Wood, T J Martin
Affiliations

Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors

S C Kukreja et al. J Clin Invest. 1988 Nov.

Abstract

A parathyroid hormone-related protein (PTHrP) has recently been isolated from tumors associated with hypercalcemia. In the present study, we tested the effects of neutralizing antisera to the PTHrP on serum calcium and urine cAMP in two animal models of malignancy-associated hypercalcemia. The animal models consisted of (a) a human squamous cell lung cancer and (b) a human laryngeal cancer, both serially carried in athymic mice. The antisera specifically reduced the elevated serum calcium and urinary cAMP levels in the tumor-bearing animals. We conclude that PTHrP plays a major role in the pathogenesis of malignancy-associated hypercalcemia.

PubMed Disclaimer

References

    1. J Histochem Cytochem. 1970 May;18(5):315-33 - PubMed
    1. J Bone Miner Res. 1988 Jun;3(3):341-6 - PubMed
    1. Endocrinology. 1978 Mar;102(3):799-805 - PubMed
    1. Endocrinology. 1980 Jul;107(1):270-3 - PubMed
    1. J Clin Endocrinol Metab. 1980 Jul;51(1):167-9 - PubMed

Publication types