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Review
. 2017 Apr 30;9(5):97.
doi: 10.3390/v9050097.

Historical Perspectives on Flavivirus Research

Michael R Holbrook  1
Affiliations
Review

Historical Perspectives on Flavivirus Research

Michael R Holbrook. Viruses. .

Abstract

The flaviviruses are small single-stranded RNA viruses that are typically transmitted by mosquito or tick vectors. These "arboviruses" are found around the world and account for a significant number of cases of human disease. The flaviviruses cause diseases ranging from mild or sub-clinical infections to lethal hemorrhagic fever or encephalitis. In many cases, survivors of neurologic flavivirus infections suffer long-term debilitating sequelae. Much like the emergence of West Nile virus in the United States in 1999, the recent emergence of Zika virus in the Americas has significantly increased the awareness of mosquito-borne viruses. The diseases caused by several flaviviruses have been recognized for decades, if not centuries. However, there is still a lot that is unknown about the flaviviruses as the recent experience with Zika virus has taught us. The objective of this review is to provide a general overview and some historical perspective on several flaviviruses that cause significant human disease. In addition, available medical countermeasures and significant gaps in our understanding of flavivirus biology are also discussed.

Keywords: Japanese encephalitis; West Nile; Zika; dengue; flavivirus; tick-borne encephalitis; yellow fever.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of major flaviviruses discussed in this article. Information was adapted from data and figures provided on Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) websites.
Figure 2
Figure 2
A time-line of historical highlights of flavivirus research.
See this image and copyright information in PMC

References

    1. Pettersson J.H., Fiz-Palacios O. Dating the origin of the genus Flavivirus in the light of Beringian biogeography. J. Gen. Virol. 2014;95:1969–1982. doi: 10.1099/vir.0.065227-0. - DOI - PubMed
    1. Westaway E.G., Brinton M.A., Gaidamovich S., Horzinek M.C., Igarashi A., Kaariainen L., Lvov D.K., Porterfield J.S., Russell P.K., Trent D.W. Flaviviridae . Intervirolgy. 1985;24:183–192. doi: 10.1159/000149642. - DOI - PubMed
    1. Blitvich B.J., Firth A.E. Insect-specific flaviviruses: A systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organization. Viruses. 2015;7:1927–1959. doi: 10.3390/v7041927. - DOI - PMC - PubMed
    1. Carter H.R. Yellow Fever, an Epidemiologicaland Historical Study of Its Place of Origin. William and Wilkins Company; Baltimore, MD, USA: 1931.
    1. Garrison F.H. An Introduction to the History of Medicine. 3rd ed. W.B. Saunders; Philadelphia, PA, USA: 1921.

MeSH terms