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. 1988 Dec;62(12):4767-9.
doi: 10.1128/JVI.62.12.4767-4769.1988.

The putative trans-activator in the MAgag region of Rous sarcoma virus is not required for cell transformation

A Dutta  1 , T Dorai, H Hanafusa
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The putative trans-activator in the MAgag region of Rous sarcoma virus is not required for cell transformation

A Dutta et al. J Virol. 1988 Dec.

Abstract

A stop codon created by oligonucleotide-directed mutagenesis in the proposed transcriptional trans-activator of Rous sarcoma virus (S. Broome and W. Gilbert, Cell 40:537-546, 1985) which truncated the trans-activator by half did not alter the transforming activity or the replication of the virus in primary chicken embryo fibroblasts. This result proves that this trans-activator is not essential for transformation of primary cells by Rous sarcoma virus.

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