Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;62(12):4778-81.
doi: 10.1128/JVI.62.12.4778-4781.1988.

Genetic stability of rotaviruses recovered from asymptomatic neonatal infections

J Flores  1 , J Sears, K Y Green, I Perez-Schael, A Morantes, G Daoud, M Gorziglia, Y Hoshino, R M Chanock, A Z Kapikian
Affiliations

Genetic stability of rotaviruses recovered from asymptomatic neonatal infections

J Flores et al. J Virol. 1988 Dec.

Abstract

The sequence of the VP7 gene from 19 rotavirus strains recovered from asymptomatically infected newborn infants was determined by direct analysis of transcript RNAs synthesized from virus present in the stool. For five viruses the entire VP7 gene was sequenced, whereas in the remaining instances only a portion of the gene could be sequenced. In 19 specimens collected over a 4-year period, only five nucleotide substitutions were detected. None of them resulted in an amino acid substitution. Examination of a 306-nucleotide segment of gene 4 in 11 specimens yielded similar results. These results suggest that the mutation rate of rotaviruses in nature is lower than that of single-stranded RNA viruses such as poliovirus and influenza virus.

PubMed Disclaimer

References

    1. Virology. 1986 Dec;155(2):434-51 - PubMed
    1. J Med Virol. 1985 Oct;17(2):135-43 - PubMed
    1. Virology. 1987 Nov;161(1):153-9 - PubMed
    1. J Virol. 1988 May;62(5):1819-23 - PubMed
    1. Lancet. 1975 Jul 12;2(7924):79 - PubMed