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. 2017 May 3;37(18):4658-4660.
doi: 10.1523/JNEUROSCI.0498-17.2017.

Insights into the Dual Role of Inflammation after Spinal Cord Injury

Ruslan Rust  1 , Julia Kaiser  2
Affiliations

Insights into the Dual Role of Inflammation after Spinal Cord Injury

Ruslan Rust et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Molecular processes after SCI. The following four sequential stages follow spinal cord injury: within the first hours, mechanical injury is associated with opening of the blood–brain barrier (BBB); over the next several days, immune cells infiltrate the injured area through the vascular system; next, activated astrocytes form a glial scar to protect the surrounding of the injured area; and, finally, limited levels of structural tissue regeneration occur several weeks up to months following SCI. The CD200 ligand is upregulated several days after SCI and is therefore temporally coexpressed with newly formed endothelial cells and the inflammatory response. Time points are reviewed in the study by Shechter and Schwartz (2013).
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References

    1. Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV (2016) Astrocyte scar formation aids central nervous system axon regeneration. Nature 532:195–200. 10.1038/nature17623 - DOI - PMC - PubMed
    1. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4:1116–1122. 10.1038/nn738 - DOI - PubMed
    1. Chitnis T, Imitola J, Wang Y, Elyaman W, Chawla P, Sharuk M, Raddassi K, Bronson RT, Khoury SJ (2007) Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. Am J Pathol 170:1695–1712. 10.2353/ajpath.2007.060677 - DOI - PMC - PubMed
    1. Cohen M, Ben-Yehuda H, Porat Z, Raposo C, Gordon S, Schwartz M (2017) Newly formed endothelial cells regulate myeloid cell activity following spinal cord injury via expression of CD200 ligand. J Neurosci 37:972–985. 10.1523/JNEUROSCI.2199-16.2017 - DOI - PMC - PubMed
    1. David S, Kroner A (2011) Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci 12:388–399. 10.1038/nrn3053 - DOI - PubMed

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