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. 2017 Apr-Jun;16(2):52-58.
doi: 10.4103/aam.aam_34_16.

Neonatal sepsis in a Nigerian private tertiary hospital: Bacterial isolates, risk factors, and antibiotic susceptibility patterns

Emmanuel Olushola Shobowale  1 , Adaobi U Solarin  2 , Charles John Elikwu  1 , Kenneth Ikenna Onyedibe  3 , Ibironke J Akinola  2 , Abiodun A Faniran  4
Affiliations

Neonatal sepsis in a Nigerian private tertiary hospital: Bacterial isolates, risk factors, and antibiotic susceptibility patterns

Emmanuel Olushola Shobowale et al. Ann Afr Med. 2017 Apr-Jun.

Abstract
in English, French

Background/objectives: Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group in spite of several attempts at mitigating its effects. This article determines the prevalence of neonatal sepsis and the pathogens responsible for sepsis as well as risk factors and outcome at the Babcock University Teaching Hospital.

Methods: A retrospective analysis of laboratory records of consecutive babies delivered within and outside our hospital suspected of having sepsis over a 1-year period.

Results: The isolation rate was 34% from 100 neonates with the predominant pathogens being coagulase-negative staphylococci (CONS), Staphylococcus aureus, and Klebsiella pneumoniae. The risk factors for sepsis were age <3 days (P = 0.03) and prematurity (P < 0.001). The mortality rate was 12% with risk factors for mortality being birth weight <2500 g (P = 0.005), prematurity (P = 0.036), premature rupture of membranes (P = 0.007), and delivery outside a tertiary hospital (P = 0.007). Meropenem, ciprofloxacin, and amikacin showed the highest rates of in vitro efficacy.

Conclusion: We highlight the prevalent pathogens in our local facility to be a combination of CONS, S. aureus, and K. pneumoniae with susceptibility patterns showing meropenem, ciprofloxacin, and amikacin to be our most effective antimicrobials in vitro.

Contexte/Objectifs:: La septicémie néonatale est une cause importante de morbidité et de mortalité dans le groupe d’âge pédiatrique, malgré plusieurs Atténuer ses effets. Cet article détermine la prévalence du sepsis néonatal et des pathogènes responsables de la septicémie, ainsi Les facteurs de risque et les résultats au Babcock University Teaching Hospital.

Méthodes:: Une analyse rétrospective des données de laboratoire des Les bébés livrés à l’intérieur et à l’extérieur de notre hôpital soupçonnés d’avoir une septicémie sur une période d’un an.

Résultats:: Le taux d’isolement était de 34% Les nouveau-nés dont les agents pathogènes prédominants sont les staphylocoques coagulases négatifs (CONS), Staphylococcus aureus et Klebsiella pneumoniae. Les facteurs de risque de sepsis étaient l’âge <3 jours (P = 0,03) et la prématurité (P <0,001). Le taux de mortalité était de 12% avec des facteurs de risque de mortalité (P = 0,005), la prématurité (P = 0,036), la rupture prématurée des membranes (P = 0,007) et la délivrance à l’extérieur d’un tertiaire Hôpital (P = 0,007). Meropenem, ciprofl oxacine et amikacine ont montré les plus hauts taux d’efficacité in vitro.

Conclusion:: Nous soulignons Pathogènes prédominants dans notre établissement local pour être une combinaison de CONS, S. aureus et K. pneumoniae avec des schémas de susceptibilité montrant Meropenem, ciprofloxacine et amikacine pour être nos antimicrobiens les plus efficaces in vitro.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Distribution of organisms causing neonatal sepsis
Figure 2
Figure 2
Antimicrobial susceptibility profiles of pathogens isolated in neonatal sepsis
See this image and copyright information in PMC

Comment in

References

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