A Case Report of Krukenbergs Tumor with Cutaneous Seeding

Abstract

A 47-year-old female patient presented with painless skin colored and erythematous papules coalesced to form plaques over lower abdomen for 10 days. She had undergone exploratory laparotomy with hysterectomy and bilateral oophorectomy 1 month ago, and histopathology was reported as Krukenbergs tumor. She was getting evaluated for primary, when she was referred to dermatology. A clinical diagnosis of cutaneous infiltration of tumor was made, and biopsy was done from a representative lesion which showed features suggestive of metastatic poorly differentiated adenocarcinoma. In the majority of cases in the past, cutaneous metastasis is seen much later in the course of the disease. High degree of suspicion and histopathology was helpful in the diagnosis of underlying malignancy in our patient.

Keywords: Cutaneous metastasis; Krukenbergs tumor; poorly differentiated adenocarcinoma.

Figure 1

(a) Erythematous to hyperpigmented infiltrated nodules and plaques, showing peau dæorange appearance. (b) Close up view

Figure 2

(a) Low power: Dermis shows diffuse infiltration of tumor cells. Lymphoplasmacytic infiltrate around blood vessels. (b) High power: Dermal tumor cells are present in cords and singles, with pleomorphic round to oval nucleus, high N:C ratio, and vesicular chromatin. Signet ring-like cells are present

Figure 3

(a) Endoscopic view of gastroesophageal junction: Friable hypertrophic growth, which on biopsy showed features suggestive of poorly differentiated adenocarcinoma. (b) Endoscopic view of fundus of the stomach