Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Nicola J Armstrong^{1

2}, Karen A Mather¹, Anbupalam Thalamuthu¹, Margaret J Wright^{3

4}, Julian N Trollor^{1

5}, David Ames^{6

7}, Henry Brodaty^{1

8}, Peter R Schofield^{9

10}, Perminder S Sachdev^{1

11}, John B Kwok^{9

10

12}

Affiliations

¹ Centre for Healthy Brain Aging, School of Psychiatry, UNSW Australia, Sydney, Australia.
² Department of Mathematics & Statistics, Murdoch University, Perth, Australia.
³ Queensland Brain Institute, University of Queensland, Brisbane, Australia.
⁴ Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
⁵ Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, Australia.
⁶ Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.
⁷ National Aging Research Institute, Melbourne, Australia.
⁸ Dementia Collaborative Research Centre - Assessment & Better Care, UNSW Australia, Sydney, Australia.
⁹ Neuroscience Research Australia, Sydney, Australia.
¹⁰ School of Medical Sciences, UNSW Australia, Sydney, Australia.
¹¹ Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia.
¹² Brain and Mind Centre - University of Sydney, Camperdown, Australia.

PMID: 28470125
DOI: 10.2217/epi-2016-0179

Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Nicola J Armstrong et al. Epigenomics. 2017 May.

. 2017 May;9(5):689-700.

doi: 10.2217/epi-2016-0179. Epub 2017 May 4.

Authors

Affiliations

¹ Centre for Healthy Brain Aging, School of Psychiatry, UNSW Australia, Sydney, Australia.
² Department of Mathematics & Statistics, Murdoch University, Perth, Australia.
³ Queensland Brain Institute, University of Queensland, Brisbane, Australia.
⁴ Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
⁵ Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, Australia.
⁶ Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.
⁷ National Aging Research Institute, Melbourne, Australia.
⁸ Dementia Collaborative Research Centre - Assessment & Better Care, UNSW Australia, Sydney, Australia.
⁹ Neuroscience Research Australia, Sydney, Australia.
¹⁰ School of Medical Sciences, UNSW Australia, Sydney, Australia.
¹¹ Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia.
¹² Brain and Mind Centre - University of Sydney, Camperdown, Australia.

PMID: 28470125
DOI: 10.2217/epi-2016-0179

Abstract

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity.

Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks.

Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model.

Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

Keywords: DNAmage; acceleration; age; aging; centenarians; epigenetic clock; longevity.

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Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Affiliations

Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources