Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct;8(10):4537-40.
doi: 10.1128/mcb.8.10.4537-4540.1988.

Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes

C E Trueblood  1 , R M Wright, R O Poyton
Affiliations

Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes

C E Trueblood et al. Mol Cell Biol. 1988 Oct.

Abstract

In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1975 Dec 10;250(23):9090-8 - PubMed
    1. Annu Rev Genet. 1971;5:257-96 - PubMed
    1. J Biol Chem. 1978 Jan 10;253(1):305-10 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jan;77(1):541-5 - PubMed
    1. Methods Enzymol. 1983;101:202-11 - PubMed

Publication types