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. 1988 Nov;85(22):8747-50.
doi: 10.1073/pnas.85.22.8747.

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium

S Supattapone  1 , S K Danoff, A Theibert, S K Joseph, J Steiner, S H Snyder
Affiliations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium

S Supattapone et al. Proc Natl Acad Sci U S A. 1988 Nov.

Abstract

We report the stoichiometric phosphorylation of an inositol 1,4,5-trisphosphate receptor-binding protein from rat brain by the cAMP-dependent protein kinase but not by protein kinase C or Ca2+/calmodulin-dependent protein kinase. This phosphorylation event does not markedly alter [3H]inositol 1,4,5-trisphosphate-binding characteristics. However, inositol 1,4,5-trisphosphate is only 10% as potent in releasing 45Ca2+ from phosphorylated, as compared with native, cerebellar microsomes. Phosphorylation of the inositol 1,4,5-trisphosphate-binding protein by the cAMP-dependent protein kinase may provide a biochemical substrate for second-messenger cross talk.

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