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Multicenter Study
. 2017 Oct;36(10):1006-1008.
doi: 10.1097/INF.0000000000001634.

Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures

Todd W Lyons  1 , Andrea T Cruz, Stephen B Freedman, Joseph L Arms, Paul L Aronson, Alesia H Fleming, Dina M Kulik, Prashant Mahajan, Rakesh D Mistry, Christopher M Pruitt, Amy D Thompson, Lise E Nigrovic; Herpes Simplex Virus Study Group of the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC)
Affiliations
Multicenter Study

Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures

Todd W Lyons et al. Pediatr Infect Dis J. 2017 Oct.

Abstract

In our multicenter cohort of infants ≤60 days of age, we identified 2646 infants with a traumatic lumbar puncture, of which 31 (1.2%) had bacterial meningitis. For every 1000 cerebrospinal fluid red blood cells/mm, cerebrospinal (cerebrospinal fluid) protein increased 1.1 mg/dL (95% confidence interval: 1.0-1.2 mg/dL).

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Conflict of interest statement

Conflicts of Interest: None of the authors have any conflicts of interest to report.

Figures

Figure 1
Figure 1
A. Plot of cerebrospinal fluid protein versus cerebrospinal fluid red blood cells in infants ≤ 60 days with a traumatic lumbar puncture, B. Test characteristics of uncorrected and corrected cerebrospinal fluid protein for the detection of bacterial meningitis in infants ≤ 60 days with a traumatic lumbar puncture Abbreviations: mg=milligram, dL=deciliter, mm3 = cubic millimeter, PPV=positive predictive value, NPV=negative predictive value, +LR=positive likelihood ratio, -LR=negative likelihood ratio, AUC=area under curve for receiver operating characteristics curve 1Slope of regression line = 0.0011 (mg/dL)/(cells/mm3) 2Significantly different compared to uncorrected CSF protein at p < 0.001 3Significantly different compared to uncorrected CSF protein at p = 0.00
See this image and copyright information in PMC

References

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