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Review
. 2017 Jul 28:258:226-253.
doi: 10.1016/j.jconrel.2017.04.043. Epub 2017 May 2.

Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review

Thiruganesh Ramasamy  1 , Hima Bindu Ruttala  2 , Biki Gupta  2 , Bijay Kumar Poudel  2 , Han-Gon Choi  3 , Chul Soon Yong  4 , Jong Oh Kim  5
Affiliations
Review

Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review

Thiruganesh Ramasamy et al. J Control Release. .

Abstract

This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10years. We provide a comprehensive overview of the different functional moieties and reducible linkages exploited in these systems, and outline their design, synthesis, and application from a therapeutic efficacy viewpoint. Furthermore, we highlight the next generation nanomedicine strategies based on this novel chemistry.

Keywords: Drug delivery; Nanocarrier; Nanomedicine; Smart chemistry.

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