Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 May 4;129(18):2462-2463.
doi: 10.1182/blood-2017-03-772087.

Alzheimer disease makes new blood contacts

Mario Merlini  1 , Katerina Akassoglou  1   2
Affiliations
Comment

Alzheimer disease makes new blood contacts

Mario Merlini et al. Blood. .

Abstract

In this issue of Blood, Chen and colleagues demonstrate an unanticipated role for the contact system in a murine model of Alzheimer disease (AD). The study bolsters the key role of vascular dysfunction in AD by identifying factor XII (FXII) activation as a new molecular player in AD pathogenesis through mechanisms linked to cerebral fibrin deposition, neuroinflammation, and neuronal damage.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: K.A. served as a consultant for Lundbeck and is a named inventor on patents and patent applications related to fibrin. M.M. declares no competing financial interests.

Figures

None
Coagulation FXII has an essential role in inflammation-mediated neuronal damage and cognitive impairment in an AD mouse model. Similar to depletion of fibrinogen, depletion of FXII decreases neuroinflammatory responses and subsequent brain pathology. Histological images have been adapted from Figure 6 in the article by Chen et al that begins on page 2547.
See this image and copyright information in PMC

Comment on

References

    1. Chen Z-L, Revenko AS, Singh P, et al. . Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice. Blood. 2017;129(18):2547-2556. - PMC - PubMed
    1. Iadecola C. The pathobiology of vascular dementia. Neuron. 2013;80(4):844-866. - PMC - PubMed
    1. Bardehle S, Rafalski VA, Akassoglou K. Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface. Front Cell Neurosci. 2015;9:354. - PMC - PubMed
    1. Davalos D, Ryu JK, Merlini M, et al. . Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012;3:1227. - PMC - PubMed
    1. Ryu JK, Petersen MA, Murray SG, et al. . Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015;6:8164. - PMC - PubMed

LinkOut - more resources