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Review
. 2017:2017:3971259.
doi: 10.1155/2017/3971259. Epub 2017 Apr 3.

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Hao Li  1 , Jing-Wei Liu  1 , Li-Ping Sun  1 , Yuan Yuan  1
Affiliations
Review

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Hao Li et al. Biomed Res Int. 2017.

Abstract

Previous studies have examined the associations of DNA methyltransferase 1 (DNMT1) polymorphisms, including single nucleotide polymorphisms rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G), with cancer risk. However, the results are inconclusive. The aim of this meta-analysis is to elucidate the associations between DNMT1 polymorphisms and cancer susceptibility. The PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure databases were searched systematically to identify potentially eligible reports. Odd ratios and 95% confidence intervals were used to evaluate the strength of association between three DNMT1 polymorphisms and cancer risk. A total of 16 studies were finally included in the meta-analysis, namely, nine studies of 3378 cases and 4244 controls for rs16999593, 11 studies of 3643 cases and 3866 controls for rs2228611, and three studies of 1343 cases and 1309 controls for rs2228612. The DNMT1 rs2228612 (A/G) polymorphism was significantly related to cancer risk in the recessive model. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.

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Figures

Figure 1
Figure 1
The flowchart of literature inclusion and exclusion.
Figure 2
Figure 2
Forest plot for the association between DNMT1 rs16999593 (T/C) polymorphism and cancer risk in the cancer type subgroup. (a) TC versus TT; (b) TC + CC versus TT.
Figure 3
Figure 3
Forest plot for the association between DNMT1 rs2228611 (G/A) polymorphism and risk of cancer in the subgroup of cancer type. (a) GA versus GG; (b) GA + AA versus GG.
Figure 4
Figure 4
Forest plot for the association between DNMT1 rs2228612 (A/G) polymorphism and cancer risk. (a) GG versus AA; (b) GG versus AA + AG.
See this image and copyright information in PMC

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