Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Sep;19(2):95-103.
doi: 10.1016/0165-2427(88)90001-3.

Antiviral and antigenic properties of recombinant porcine interferon gamma

B Charley  1 , K McCullough, S Martinod
Affiliations

Antiviral and antigenic properties of recombinant porcine interferon gamma

B Charley et al. Vet Immunol Immunopathol. 1988 Sep.

Abstract

Recombinant porcine interferon gamma (rPoIFN gamma) induced a dose-dependent inhibition of the cytopathic effect produced by vesicular stomatitis virus (VSV) challenge of both homologous and heterologous (bovine) cell lines. In addition, an antiviral effect of rPoIFN gamma was demonstrable against the coronavirus transmissible gastroenteritis virus (TGEV) infection of porcine epithelial cells and of pulmonary macrophages. A rabbit anti-PoIFN gamma antiserum was prepared and shown to specifically neutralize the antiviral effects of natural and recombinant porcine IFN gamma preparations. This antiserum could also neutralize recombinant bovine IFN gamma but not recombinant human IFN gamma. These results suggest antigenic homology of porcine and bovine IFN gamma but antigenic differences between these molecules and human IFN gamma.

PubMed Disclaimer

References

    1. Babiuk L.A., Bielefeldt Ohmann H., Gifford G., Czarniecki C.W., Scialli V.T., Hamilton E.B. Effect of bovine α1 interferon on bovine herpes virus type 1 induced respiratory disease. J. Gen. Virol. 1985;66:2283–2394. - PubMed
    1. Bielefeldt Ohmann H., Babiuk L.A. In vitro and systemic effects of recombinant bovine interferons on natural cell-mediated cytotoxicity in healthy and bovine herpes virus 1 infected cattle. J. Interferon Res. 1985;5:551–564. - PubMed
    1. Bielefeldt Ohmann H.B., Babiuk L.A. Alteration of some leukocyte functions following in vivo and in vitro exposure to recombinant bovine alpha and gamma interferon. J. Interferon Res. 1986;6:123–136. - PubMed
    1. Branca A.A., Baglioni C. Evidence that type I and II interferons have different receptors. Nature. 1981;294:768–770. - PubMed
    1. Capon D.J., Shepard M., Goeddel D.V. Two distinct families of human and bovine interferon α genes are coordinately expressed and encode functional polypeptides. Mol. Cell. Biol. 1985;5:768–779. - PMC - PubMed

LinkOut - more resources