Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Nov;19(11):1499-1501.
doi: 10.1111/dom.12994. Epub 2017 Jun 9.

Metformin-associated lactic acidosis: Moving towards a new paradigm?

Affiliations
Editorial

Metformin-associated lactic acidosis: Moving towards a new paradigm?

Thomas A Bicsak et al. Diabetes Obes Metab. 2017 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representation of lactic acidosis risk as a function of metformin accumulation and other precipitating factors

Comment on

References

    1. Lalau J‐D, Kajbaf F, Protti A, Christensen MM, Broe ME, Wiernsperger N. Metformin‐associated lactic acidosis (MALA): moving towards a new paradigm. Diabetes Obes Metab. 2017. https://doi.org/10.1111/dom.12974. - DOI - PubMed
    1. Connelly PJ, Lonergan M, Soto‐Pedre E, Donnelly L, Zhou K, Pearson ER. Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: a GoDarts study. Diabetes Obes Metab. 2017. https://doi.org/10.1111/dom.12978. - DOI - PMC - PubMed
    1. Neal A, Rountree AM, Philips CW, et al. Quantification of low‐level drug effects using real‐time, in vitro measurement of oxygen consumption rate. Toxicol Sci. 2015;148(2):594‐602. - PMC - PubMed
    1. Ozeki T, Kawato R, Watanabe M, et al. A fatal case of metformin‐associated lactic acidosis. Intern Med. 2016;55(7):775‐778. - PubMed
    1. Zibar L, Zibar K. Hemodialysis‐refractory metformin‐associated lactate acidosis with hypoglycemia, hypothermia, and bradycardia in a diabetic patient with belated diagnosis and chronic kidney disease. Int J Clin Pharmacol Ther. 2017;55(4):348‐351. - PubMed