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doi:10.1097/PCC.0000000000001158

Comment

. 2017 May;18(5):501-502.

doi: 10.1097/PCC.0000000000001158.

The authors reply

John C Lin¹, Philip C Spinella, Julie C Fitzgerald, Marisa Tucci, Jenny L Bush, Vinay M Nadkarni, Neal J Thomas, Scott L Weiss

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Affiliation

¹ Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Division of Critical Care Medicine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Pediatric Critical Care Medicine, Departments of Pediatrics and Public Health Sciences, Penn State University College of Medicine, Hershey, PA; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; for the Sepsis Prevalence, Outcomes, and Therapy Study.

PMID: 28475543
PMCID: PMC5506827
DOI: 10.1097/PCC.0000000000001158

Comment

The authors reply

John C Lin et al. Pediatr Crit Care Med. 2017 May.

. 2017 May;18(5):501-502.

doi: 10.1097/PCC.0000000000001158.

Authors

John C Lin¹, Philip C Spinella, Julie C Fitzgerald, Marisa Tucci, Jenny L Bush, Vinay M Nadkarni, Neal J Thomas, Scott L Weiss

Affiliation

¹ Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Division of Critical Care Medicine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Pediatric Critical Care Medicine, Departments of Pediatrics and Public Health Sciences, Penn State University College of Medicine, Hershey, PA; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; for the Sepsis Prevalence, Outcomes, and Therapy Study.

PMID: 28475543
PMCID: PMC5506827
DOI: 10.1097/PCC.0000000000001158

No abstract available

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Comment on

New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality.
Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL; Sepsis Prevalence, Outcomes, and Therapy Study Investigators. Lin JC, et al. Pediatr Crit Care Med. 2017 Jan;18(1):8-16. doi: 10.1097/PCC.0000000000000978. Pediatr Crit Care Med. 2017. PMID: 28060151 Free PMC article.
New or Progressive Multiple Organ Dysfunction Syndrome as Surrogate Outcome for Mortality in Pediatric Severe Sepsis Trials.
Baldanzi G, Delgado AF. Baldanzi G, et al. Pediatr Crit Care Med. 2017 May;18(5):500-501. doi: 10.1097/PCC.0000000000001148. Pediatr Crit Care Med. 2017. PMID: 28475542 No abstract available.

References

1. Lin JC, Spinella PC, Fitzgerald JC, et al. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017;18(1):8–16. - PMC - PubMed
1. Baldanzi G, Delgado AF. New or progressive multiple organ dysfunction syndrome as surrogate outcome for mortality in pediatric severe sepsis trials. Pediatr Crit Care Med. 2017 IN PRESS. - PubMed
1. Workman JK, Larsen GY. Searching for a Pediatric Severe Sepsis Phenotype: Are We There Yet? Pediatr Crit Care Med. 2017;18(1):82–83. - PubMed
1. Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med. 1989;8(4):431–440. - PubMed
1. Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med. 1996;125(7):605–613. - PubMed

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[1] Lin JC, Spinella PC, Fitzgerald JC, et al. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017;18(1):8–16. - PMC - PubMed

[2] Lin JC, Spinella PC, Fitzgerald JC, et al. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017;18(1):8–16. - PMC - PubMed

[3] Baldanzi G, Delgado AF. New or progressive multiple organ dysfunction syndrome as surrogate outcome for mortality in pediatric severe sepsis trials. Pediatr Crit Care Med. 2017 IN PRESS. - PubMed

[4] Baldanzi G, Delgado AF. New or progressive multiple organ dysfunction syndrome as surrogate outcome for mortality in pediatric severe sepsis trials. Pediatr Crit Care Med. 2017 IN PRESS. - PubMed

[5] Workman JK, Larsen GY. Searching for a Pediatric Severe Sepsis Phenotype: Are We There Yet? Pediatr Crit Care Med. 2017;18(1):82–83. - PubMed

[6] Workman JK, Larsen GY. Searching for a Pediatric Severe Sepsis Phenotype: Are We There Yet? Pediatr Crit Care Med. 2017;18(1):82–83. - PubMed

[7] Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med. 1989;8(4):431–440. - PubMed

[8] Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med. 1989;8(4):431–440. - PubMed

[9] Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med. 1996;125(7):605–613. - PubMed

[10] Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med. 1996;125(7):605–613. - PubMed

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